|
KMID : 0882420080750030262
|
|
Korean Journal of Medicine
2008 Volume.75 No. 3 p.262 ~ p.266
|
|
|
Male climacteric syndrome -Late Onset Hypogonadism (LOH) in males-
|
|
Yoo Soon-Jip
|
|
|
Abstract
|
|
|
Male climacteric syndrome is a clinical and biochemical syndrome characterized by the decline in serum concentration
of biologically active forms of testosterone with aging in men which may result in detrimental effect on the quality of life(QOL) and adversely affect the function of multiple organ systems. Androgen replacement therapy may have favorable
effect in QOL, body composition, cardiovascular disease, sexual dysfunction and osteoporosis. Controversy in defining the clinical syndrome and in long-term effect of androgen replacement therapy continues.
An international consensus document was recently published and provides guidance on the diagnosis, treatment and
monitoring of late-onset hypogonadism (LOH) in males. The diagnosis of LOH requires biochemical and clinical components. Any clinical intervention testosterone treatment should be judged on a balance of risk versus benefit. There
have been potential concerns regarding the effects of testosterone on prostate disease and polycythemia. The available
treatment methods have increased in recent years with the availability of a number of testosterone preparations which can
reliably produce physiological serum concentrations. Periodic physician’s evaluations is required to assess the clinical
response and to avoid potential adverse events and must be tailored individually.
|
|
|
KEYWORD
|
|
|
Male climacteric syndrome, Late-onset hypogonadism, Testosterone, Hormone repleacement therapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|